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. 2016 Jul 12;17(7):1051. doi: 10.3390/ijms17071051

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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STC-1 acts a modulator for renal injury via affecting ROS-mediated multiple pathways. STC-1 is an effective ROS scavenger, which affects the levels of phosphorylated mitogen-activated protein kinase kinase kinase (p-MEKK-1), c-Jun N-terminal kinase (p-JNK), nuclear factor (NF) κB, extracellular signal-regulated kinase (p-ERK), IkB kinase (p-IKK), apoptosis signal-regulating kinase 1 (ASK-1), p53 and caspase-3. STC-1 affects ROS-mediated IKK-NF-κB, PKC-ERK-NF-κB, ASK-1-NF-κB, p53 and MEKK-JNK pathways, and improves anti-inflammation, anti-oxidant and anti-apoptosis activities by increasing level of superoxide dismutase (SOD) and reducing the level of capase-3, p53, interleukin-6 (IL-6) and IFN-γ.