Table 2.
Parameter | Sarcosine (n = 27) | Placebo (n = 30) | p |
---|---|---|---|
SBP (mm Hg) | 123.6 ± 16.3 (117.2–129.9) | 126.7 ± 16.4 (120.6–132.8) | NS |
DBP (mm Hg) | 74.4 ± 9.2 (70.8–78.0) | 79.3 ± 9.2 (75.9–82.7) | NS |
TC (mg/dL) | 202.8 ± 31.9 (190.4–215.1) | 221.2 ± 54.1 (201.0–241.4) | NS |
HDL (mg/dL) | 45.4 ± 18.1 (38.4–52.4) | 45.5 ± 14.8 (40.0–51.1) | NS |
LDL (mg/dL) | 126.0 ± 27.5 (115.3–136.6) | 143.6 ± 43.9 (127.6–160.2) | NS |
TGA (mg/dL) | 155.6 ± 77.8 (125.4–185.8) | 161.3 ± 106.8 (121.4–201.2) | NS |
FPG (mg/dL) | 96.7 ± 14.3 (91.2–102.3) | 97.6 ± 22.9 (89.0–106.1) | NS |
TSH (μIU/mL) | 1.7 ± 0.9 (1.3–2.0) | 1.5 ± 0.7 (1.3–1.8) | NS |
PRL (ng/mL) | 33.8 ± 31.3 (21.7–45.9) | 31.5 ± 36.6 (17.9–45.1) | NS |
Antihypertensive treatment | 4 (14.8%) | 7 (23.3%) | NS |
Lipid-lowering treatment | 1 (3.7%) | 2 (6.7%) | NS |
Antidiabetic treatment | 0 | 1 (3.7%) | NS |
Metabolic syndrome | 13 (48.1%) | 18 (60.0%) | NS |
Dyslipidemia | 22 (81.5%) | 25 (83.3%) | NS |
Impaired fasting glucose | 8 (29.6%) | 9 (30.0%) | NS |
Body Composition | |||
Weight (kg) | 90.4 ± 21.1 (82.1–98.8) | 86.4 ± 16.3 (80.3–92.5) | NS |
BMI (kg/m2) | 34.1 ± 22.5 (25.2–43.0) | 29.4 ± 4.9 (27.6–31.3) | NS |
FMI (kg/m2) | 11.6 ± 8.1 (8.4–14.8) | 10.5 ± 4.7 (8.7–12.2) | NS |
Abdominal circumference (cm) | 103.4 ± 16.5 (96.8–109.9) | 103.3 ± 11.9 (98.9–107.8) | NS |
Waist circumference (cm) | 95.3 ± 15.3 (89.3–101.4) | 96.1 ± 10.7 (92.1–100.1) | NS |
Hip circumference (cm) | 106.8 ± 14.6 (101.0–112.5) | 105.6 ± 12.4 (100.9–110.2) | NS |
Leg circumference (cm) | 53.5 ± 7.0 (50.7–56.3) | 53.8 ± 6.3 (51.4–56.2) | NS |
WHR | 0.89 ± 0.10 (0.86–0.93) | 0.91 ± 0.09 (0.88–0.95) | NS |
Total body fat (kg) | 30.7 ± 14.8 (24.9–36.6) | 30.4 ± 12.7 (25.6–35.1) | NS |
Total body fat (%) | 32.5 ± 10.4 (28.3–36.6) | 34.3 ± 11.4 (30.0–38.5) | NS |
Lean body mass (kg) | 59.7 ± 10.2 (55.7–63.8) | 55.9 ± 11.0 (51.8–60.0) | NS |
Lean body mass (%) | 67.5 ± 10.4 (63.4–71.6) | 65.6 ± 11.4 (61.4–69.9) | NS |
Data given as: n (%) or mean ± standard deviation (95% CI); SBP = systolic blood pressure; DBP = diastolic blood pressure; TC = total cholesterol; HDL = high-density lipoproteins; LDL = low-density lipoproteins; TGA = triglycerides; FPG = fasting plasma glucose; TSH = thyroid-stimulating hormone; PRL = prolactin; BMI = body mass index; FMI = fat mass index; WHR = waist-to-hip ratio; NS = non significant.