Table 1.

Bilogical effects of Angiotensin A.

Angiotensin A		References
Human embryonic kidney cells HEK-293	No difference in AT1 affinity to Ang A and Ang II ↑ affinity of AT2 for Ang A than for Ang II	[17]
Vascular smooth-muscle cells	Dose-dependent ↑ in cytosolic calcium inhibited by AT1 antagonist EXP-3174	[17]
	proliferative effect Ang A > to Ang II	[20]
Abdominal aorta New Zealand White rabbits	Vasoconstriction ↓ in vessels from animals fed with atherogenic diet	[19]
Isolated perfused kidney	Dose-dependent vasoconstriction 90% of the maximal effect of Ang II inhibited by AT1 antagonist EXP-3174 no effect of AT2 antagonist PD123319	[17]
Normotensive rats intrarenal administration	↓ renal blood flow and ↑ renal vascular resistance ↓ effect of Ang A compared to Ang II improved by candesartan	[18]
Normotensive rats i.v. administration	↑ BP ↓ by AT1-receptor blocker losartan no effect of AT2-antagonist PD123319	[20]
Spontaneously hypertensive rats i.v. administration	↑ BP both SHR and controls ↓ by AT1-receptor blocker candesartan no effect of AT2-antagonist PD123319 dose-dependent ↓ renal blood flow and ↑ renal vascular resistance in both SHR and controls ↓ effect of Ang A compared to Ang II no vasodilator response to Ang A or Ang II stimulation improved by candesartan no effect of AT2-antagonist PD123319	[18]
AT1-knockout mice	↑ BP in wild-type mice at ≈10× ↑ concentrations than Ang II no effect on BP in AT1A-knockout mice	[17]
	↑ BP and cortical vascular resistance and ↓ cortical blood flow in wild-type mice by Ang A and Ang II abolished in AT1A-knockout mice	[18]
AT2-knockout mice	↑ cortical vascular resistance and ↓ cortical blood flow inhibited by candesartan no effect of AT2-antagonist PD123319	[18]