Table 3.
Pathway analysis by the David database of high abundance analytes secreted by undifferentiated hbmMSC and hsubMSC and 10 potential interaction partners as predicted by the STRING database (input of analytes as summarised in Tables S1 and S2). Associated KEGG-pathways with p-values of significance as well as analytes involved are shown.
| hbmMSC, Undifferentiated—High Abundance Analytes | |||
|---|---|---|---|
| Associated KEGG-Pathway | p-Value | Analytes Involved (Entrez Gene ID) | Predicted Genes (Entrez Gene ID) |
| Complement and coagulation cascades | 3.8 × 10−5 | SerpinE1 (5054) Complement factor D (1675) PLAT (5327) PLG (5340) PLAU (5328) |
IGF1 (3479) IGF2 (3481) PLAU (5328) IL-17RA (23,765) CCR2 (1231) PLAT (5327) PLG (5340) PRDM1 (639) PDGFRA (5156) CD47 (961) |
| p53 signalling pathway | 9.3 × 10−4 | IGF1 (3479) IGFBP-3 (3486) Serpin E1 (5054) Thrombospondin 1 (7057) |
|
| Prostate cancer | 2.0 × 10−3 | IGF1 (3479) IGF2 (3481) PDGF AA (5154) PDGFRA (5156) |
|
| Cytokine-cytokine receptor interaction | 6.0 × 10−3 | PDGF AA (5154) PDGFRA (5156) IL-17 (3506) IL-17RA (23,765) MCP-1 (6347) |
|
| Glioma | 1.4 × 10−2 | IGF1 (3479) PDGF AA (5154) PDGFRA (5156) |
|
| Melanoma | 1.8 × 10−2 | IGF1 (3479) PDGF AA (5154) PDGFRA (5156) |
|
| Focal adhesion | 1.9 × 10−2 | IGF1 (3479) PDGF AA (5154) PDGFRA (5156) Thrombospondin 1 (7057) |
|
| hsubMSC, Undifferentiated-High Abundance Analytes | |||
| Associated KEGG-Pathway | p-Value | Analytes Involved (Entrez Gene ID) | Predicted Genes (Entrez Gene ID) |
| Cytokine-cytokine receptor interaction | 6.0 × 10−5 | IL-17 (3506) IL-17RA (23,765) MCP-1 (6347) ENA-78 (6374) IL-8 (3576) CXCR1 (3577) CXCR2 (3579) |
LRP5 (4041) LRP6 (4040) CXCR1 (3577) CXCR2 (3579) PLAU (5328) PLAT (5327) PLG (5340) CCR2 (1231) IL-17RA (23,765) RELA (5970) |
| Chemokine signalling pathway | 1.4 × 10−4 | MCP-1 (6347) ENA-78 (6374) IL-8 (3576) CXCR1 (3577) CXCR2 (3579) RELA (5970) |
|
| Epithelial cell signalling in Helicobacter pylori infection | 9.3 × 10−4 | IL-8 (3576) CXCR1 (3577) CXCR2 (3579) RELA (5970) |
|
| Complement and coagulation cascades | 9.7 × 10−4 | PLAU (5328) PLAT (5327) PLG (5340) Serpin E1 (5054) |
|
| NOD-like receptor signalling pathway | 1.4 × 10−2 | MCP-1 (6347) RELA (5970) IL-8 (3576) |
|
| Wnt signalling pathway | 7.1 × 10−2 | Dkk-1 (22,943) LRP5 (4041) LRP6 (4040) |
|