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Upregulation of melanogenesis by SOX9. cAMP is elevated following UVB radiation and expression of α-MSH. α-MSH activates the PKA pathway to phosphorylate CREB and upregulate SOX9. Activated CREB and SOX9 induce MITF gene expression. MITF upregulation induces TYR expression leading to induction of melanogenesis. UVB irradiation upregulates SOX9 and activates the MITF promoter followed by TYRP2 induction.
