Figure 2.

Modification of glutamate signaling via glucocorticoid signaling under dietary zinc deficiency. Extracellular glucocorticoid [GC] concentration in the hippocampus increased by dietary zinc deficiency can elevate glutamatergic neuron activity via modification of intracellular Ca²⁺ signaling as shown by the two long black arrows. Grey triangle, grey square, and grey circle show increases in extracellular GC, intracellular Ca²⁺, and extracellular glutamate, respectively.