PD-1 |
Programmed cell death protein 1 |
PD-L1 |
Programmed death-ligand 1 |
FDA |
Food and Drug Administration |
mAbs |
Monoclonal antibodies |
DCs |
Dendritic cells |
NK |
Natural killer |
NKT |
Natural killer T |
ITIM |
Immune tyrosine-based inhibitory motif |
ITSM |
Inhibitory tyrosine-based switch motif |
Ig |
Immune globin |
IFN-γ |
Interferon-γ |
TNF-α |
Tumor necrosis factor-α |
VEGF |
Vascular endothelial growth factor |
GM-CSF |
Granulocyte-macrophage colony-stimulating factor |
IL |
Interleukin |
PENT |
Phosphatase and tensin homolog |
Treg |
Regulatory T cells |
TIL |
Tumor-infiltrating lymphocytes |
ZAP |
Zeta-chain-associated protein |
CTLs |
Cytotoxic T lymphocytes |
APCs |
Antigen presenting cells |
MHC |
Major histocompatibility complex |
ADCC |
Antibody-dependent cellular toxicity |
NSCLC |
Non-small cell lung cancer |