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The effect of 3,3′-diindolylmethane on Wnt/β-catenin signaling. The Wnt/β-catenin signaling pathway is modulated by 3,3′-diindolylmethane (DIM). DIM negatively regulates c-Myc, Fos, and Cyclin D1 through the inhibition of β-catenin. Abbreviations: DIM, 3,3′-diindolylmethane; p, phosphorylated; c-Myc, FOS. T arrow: inhibition; Up arrow: increase; down arrow: decrease.
