Figure 3.

Dose-dependent vasorelaxant effects of 5-(hydroxymethyl)furfural, p-coumaric acid, and trans-ferulic acid in porcine coronary arteries (A) and vasorelaxant responses to bradykinin in porcine coronary arteries following incubation for 18 h with a medium containing a high sodium concentration (160 mmol/L) in presence or absence of 5-(hydroxymethyl)furfural (0.1 mmol/L), p-coumaric acid (0.1 mmol/L), and trans-ferulic acid (0.1 mmol/L) (B) and pre-treated with L-NAME (an inhibitor of eNOS, 0.1 mmol/L) (C). Relaxant responses are expressed as the percentage of relaxation of the initial tone induced by U46619. Values are expressed as mean ± SEM from n = 8 to 10 experiments. Concentration-response curves were compared using two-way ANOVA. “*” stands for p < 0.05 vs. NaCl.