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. 2016 Jul 22;17(7):1191. doi: 10.3390/ijms17071191

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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LTG decreased sIPSC frequency in CA1 PCs without affecting mIPSC frequency. (A1) (Top) Whole-cell voltage-clamp recordings from a CA1 PC; (Middle and bottom) Traces of sIPSCs recorded at −70 mV in the control (black) and LTG (100 µM) (gray); (A2,A3) Cumulative distributions of sIPSC inter-event intervals (A2) and amplitudes (A3) from the control (black) and LTG (gray). Insets show the bar graph summaries of the cell averages (n = 8) for the frequency (A2) and amplitude (A3). ** p < 0.01; (B1) (Top) Traces of mIPSCs recorded at −70 mV in control conditions (black); (Bottom) Events in the presence of LTG (100 µM) application (gray); (B2,B3) Cumulative distributions of mIPSC inter-event intervals (B2) and amplitudes (B3) from the control (black) and LTG (gray). Insets show the bar graph summaries of the ell averages (n = 6) for the frequency (B2) and amplitude (B3), respectively. * p < 0.05.