Figure 1. Diagrammatic illustration of sequence modules and their relative positions in the cps promoter region of invasive pneumococcal isolates.

(A) Sequence diversity among the strains representing the 22 WZY-dependent IPD types. (B) Sequence diversity among the five type-6B promoter strains used in Figs 6 and 7. (C) Independence of the promoter sequence from the coding region (capsular type). Sequence modules are indicated with colored strips at the bottom. The size of each sequence (bp) and serotype of the source strain are indicated at the left and right sides, respectively. The numbers following the serotype icons indicated the different strains of the same serotypes.