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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Placenta. 2016 Jun 11;44:61–68. doi: 10.1016/j.placenta.2016.06.004

Figure 2.

Figure 2

Effects of BaP on PTGS2 are mediated through AHR. (A) There was no effect of BaP on AHR mRNA expression. (B) Similarly, BaP exposure did not influence ARNT mRNA expression. (C) A representative western blot demonstrates complete ablation of AHR expression with transfection of AHR siRNA. (D) Densitometric analysis of PTGS2 western blots from all subjects demonstrates up-regulation of PTGS2 protein expression with BaP treatment in the setting of control siRNA transfection (*p<0.001 in comparison to control siRNA and vehicle). With AHR ablation, however, BaP treatment resulted in significant suppression of PTGS2 expression (^p=0.007 in comparison to control siRNA and BaP treatment).