Table 2. Prescribed interventions and medications at discharge/after consultation according to stages of renal function (eGFR with CKD-EPI equation).
| All | CKD-EPI ≥80 ml/min/1.73 m2 | CKD-EPI 50–79 ml/min/1.73 m2 | CKD-EPI 30–49 ml/min/1.73 m2 | CKD-EPI <30 ml/min/1.73 m2 | P value | |
|---|---|---|---|---|---|---|
| No. of patients | 2398 | 842 | 1133 | 334 | 89 | |
| Management Strategy (%) | ||||||
| Rate control | 38.4 | 33.4 | 38.5 | 45.8 | 56.2 | <0.0001 |
| Rate and rhythm control | 44.5 | 48.3 | 44.3 | 40.1 | 25.8 | |
| Rhythm control only | 13.3 | 15.0 | 13.6 | 8.1 | 12.4 | |
| Observation | 3.9 | 3.3 | 3.6 | 6.0 | 5.6 | |
| Interventions (%) | ||||||
| (on inpatients only) | 1647 | 570 | 762 | 250 | 65 | |
| Pharmacological cardioversion | 29.2 | 33.0 | 28.9 | 25.3 | 15.6 | 0.0095 |
| Electrical cardioversion | 24.2 | 25.3 | 25.5 | 21.5 | 9.4 | 0.0220 |
| Catheter ablation | 9.6 | 15.9 | 8.3 | 2.0 | 0 | <0.0001 |
| Pacemaker implantation | 4.2 | 3.5 | 5.0 | 3.2 | 4.6 | 0.4771 |
| ICD Implantation | 1.0 | 0.9 | 0.7 | 2.4 | 1.5 | 0.1020[*] |
| Surgical therapy of AF | 0.3 | 0.5 | 0.3 | 0 | 0 | 0.6601[*] |
| Antithrombotic treatments (%) | ||||||
| None | 4.0 | 6.4 | 2.7 | 2.7 | 2.2 | 0.0002 |
| Antiplatelets | 34.3 | 29.7 | 35.3 | 41.3 | 39.3 | 0.0009 |
| Oral anticoagulant | 81.4 | 80.0 | 82.9 | 82.6 | 69.7 | 0.0104 |
| Vitamin K antagonists | 90.4 | 90.8 | 88.7 | 93.5 | 98.4 | 0.0127 |
| NOAC | 9.7 | 9.4 | 11.3 | 6.5 | 1.6 | 0.0134 |
| Oral anticoagulant if indicated** | 83.0 | 82.8 | 84.3 | 83.1 | 69.7 | 0.0058 |
| of whom Vit K antagonists | 90.7 | 91.2 | 88.9 | 93.5 | 98.4 | 0.0153 |
| of whom NOAC | 9.4 | 8.9 | 11.1 | 6.5 | 1.6 | 0.0166 |
| Antiarrhythmic drugs (%) | ||||||
| At least one | 35.4 | 35.8 | 37.0 | 32.1 | 24.7 | 0.0633 |
| Amiodarone | 21.2 | 19.4 | 21.5 | 24.9 | 21.3 | 0.2124 |
| Beta-blockers | 70.7 | 68.4 | 70.6 | 76.6 | 71.9 | 0.0483 |
| Digoxin | 20.1 | 17.7 | 21.4 | 22.5 | 18.0 | 0.1372 |
| ACE inhibitors | 44.2 | 41.1 | 48.2 | 42.9 | 27.0 | <0.0001 |
| ARBs | 21.5 | 18.8 | 22.7 | 26.7 | 13.5 | 0.0039 |
| Diuretics | 52.7 | 39.4 | 54.5 | 72.5 | 80.9 | <0.0001 |
| Aldosterone blockers | 25.5 | 19.4 | 26.0 | 38.6 | 27.3 | <0.0001 |
NOAC, Non-VKA Oral AntiCoagulant. ACE, angiotensin converting enzyme. ARB, angiotensin receptor blockers. if indicated**, CHA2DS2-VASc ≥ 2 or pharmacological cardioversion planned. *Chi-2 or Fisher exact test used for binary variables.