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. 2016 Jul 28;6:29792. doi: 10.1038/srep29792

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Confocal microscopy to evaluate the dendrite and spine morphology (synaptic plasticity) of SKNMC cells after 72 hours of NIR treatment in the absence (C) or presence (D) of MNPs in compare to control (A,B): Healthy dendritic and spine morphology of SKNMC cells is evident for all treatments. This suggests NIR phototargeting did not alter the neuronal synaptic plasticity and thus, similar to short-term effect (Figs 3 and 4), long term effect of MNPs-NIR phototargeting potentiate towards the safe use of this novel approach.