Figure 7. Proposed mechanism for efficacious targeting, delivery, release, and monitoring of therapeutics to brain using transient NIR photonics with MNPs for noninvasive brain targeting: An in silico-controlled, non-invasive magnetic force will drive MNPs across BBB and simultaneously NIR phototargeting can cause release of associated drugs (transitory optoelectronic excitation-mediated molecular vibrations on MNPs surfaces, even for short NIR laser exposure, change the charge distribution of MNPs surfaces and subsequently the ionic interaction of drugs can be broken with subsequent drug release).

Also, while MNPs alone are used for MRI imaging; a “MNP-NIR sensitive fluorescent materials::core-shell” template can be an excellent use for multi-color imaging modalities. Combining fluorescent liposomes, hydrogels, carbon dots, or matrix of upconversion materials such as Erbium, Thulium, etc., can be used for this purpose because these materials can emit different color fluorescent lights depending on NIR wavelength.