Table 4. Patient characteristics of different SNPs associated with GDM.
| N | TT | TC | CC | p value TT vs. CC |
|---|---|---|---|---|
| 223 | 223 | 110 | ||
| rs290487 | ||||
| FPG (mmol/l) | 4.5 ± 1.4 | 4.7 ± 1.6 | 4.8 ± 1.7 | 0.022 |
| 2hPPG (mmol/l) | 7.1 ± 2.0 | 8.0 ± 1.9 | 8.6 ± 1.9 | 7.13E-15 |
| FIns (mu/l) | 6.1 ± 1.6 | 7.0 ± 1.6 | 7.2 ± 1.7 | 8.33E-13 |
| HbA1c (%) | 5.2 ± 1.1 | 5.5 ± 1.2 | 5.7 ± 1.2 | 4.06E-06 |
| HOMA-IR | 1.2 ± 0.2 | 1.5 ± 0.2 | 1.7 ± 0.2 | 1.99E-104 |
| HOMA-B | 119.2 ± 14.1 | 117.0 ± 13.4 | 110.4 ± 13.0 | 4.26E-11 |
| Ins 3-h AUC (mu·l−1·h) | 190.1 ± 23.5 | 163.2 ± 26.3 | 155.6 ± 21.4 | 6.28E-57 |
| N | CC | CG | GG | p value CC vs. GG |
| 334 | 165 | 57 | ||
| rs6585194 | ||||
| FPG (mmol/l) | 4.7 ± 1.7 | 4.6 ± 1.7 | 4.5 ± 1.9 | 0.125 |
| 2hPPG (mmol/l) | 8.4 ± 1.9 | 7.0 ± 1.7 | 6.5 ± 1.8 | 3.28E-21 |
| FIns (mu/l) | 7.3 ± 1.7 | 6.1 ± 1.7 | 5.9 ± 1.7 | 2.27E-14 |
| HbA1c (%) | 5.5 ± 1.0 | 5.2 ± 1.2 | 5.1 ± 1.1 | 9.17E-05 |
| HOMA-IR | 1.5 ± 0.2 | 1.3 ± 0.2 | 1.2 ± 0.2 | 8.72E-56 |
| HOMA-B | 121.0 ± 13.9 | 119.5 ± 14.2 | 118.2 ± 13.8 | 0.028 |
| Ins 3-h AUC (mu·l−1·h) | 143.4 ± 19.2 | 146.5 ± 21.9 | 178.6 ± 22.0 | 1.62E-65 |
| N | AA | AG | GG | p value AA vs. GG |
| 267 | 232 | 57 | ||
| rs7094463 | ||||
| FPG (mmol/l) | 4.8 ± 1.8 | 4.6 ± 1.7 | 4.6 ± 1.8 | 0.223 |
| 2hPPG (mmol/l) | 8.4 ± 1.8 | 7.5 ± 1.8 | 6.5 ± 1.8 | 2.33E-13 |
| FIns (mu/l) | 7.3 ± 1.7 | 6.4 ± 1.8 | 6.0 ± 1.7 | 3.99E-29 |
| HbA1c (%) | 5.7 ± 1.2 | 5.2 ± 1.0 | 5.1 ± 1.1 | 2.93E-08 |
| HOMA-IR | 1.5 ± 0.2 | 1.3 ± 0.2 | 1.2 ± 0.2 | 6.81E-53 |
| HOMA-B | 109.6 ± 12.9 | 114.7 ± 13.2 | 116.2 ± 14.0 | 3.67E-07 |
| Ins 3-h AUC (mu·l−1·h) | 141.1 ± 18.7 | 154.3 ± 20.8 | 181.7 ± 21.5 | 1.48E-112 |
Pre-BMI, body mass index of mothers before pregnancy; FPG, fasting plasma glucose; 2-h 75 g glucose, two -hour post-challenge plasma glucose; TC, total cholesterol; LDL-C, low-density lipoprotein cholesterol; Fins, fasting plasma insulin; HOMA-IR, Homeostasis model assessment of insulin resistance; HOMA-B, Homeostasis model assessment of beta-cell function; Ins 3-h AUC, total of plasma insulin area under the curve in three hours.