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. 2016 Jul 28;6:30505. doi: 10.1038/srep30505

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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BAPN (cross-link inhibitor) or genipin (cross-link inducer) were added at time point “0” to (a) porcine and (b) human anterior segments in perfusion culture. Outflow rates were monitored for a further 69-75 hours. Average outflow facilities at 75 hours after treatment were 0.44 (control), 0.494 (BAPN) and 0.159 (genipin) μl/min/mm Hg for porcine anterior segments and 0.365 (control), 0.489 (BAPN) and 0.321 (genipin) μl/min/mm Hg for human anterior segments. Error bars are the standard error of the mean. *p < 0.05; **p < 0.01. (c) Masson’s trichrome histological staining of human TM tissue post-perfusion at 20× and 100×. Immunostaining with fibronectin (red) and fibrillin-1 antibodies (green) are also shown. The cornea is oriented toward the left of each image and the sclera at the right. SC = Schlemm’s canal. Scale bars for immunostained images = 20 μm.