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Schematic diagram of the chimeric human/mouse MHC class I gene. (A) Schematic diagram of the monochain chimeric human/mouse MHC class I gene showing the HHD structure of the chimeric human α1, α2, and β2m HLA-A11/murine H-2 α3 molecule. The murine H2 α3 domain is covalently linked to human β2m via a 15 amino acid linker. (B) Liner representation of the final construct.
