Table 5.

Factors adjusting the hydrolytic degradation rate of PLGA MPs/NPs.

Factors

Polymer related factors

Lactide/glycolide ratio

MW, Polymer end group, Glass transition temperature (Tg), Glass transition temperature (glassy, rubbery), and cristalinity

Particle related factors

Particle size, surface structure and morphology, Shape, Porosity, Loading percent

Protein related factors

MW, Solubility, Distribution Coefficient, Hydrophobicity

Number of free thiol groups and/or disulfide bonds

Environmental related factors

pH, Temperature, Ionic strength, Sink condition, Salts, Additives, Plasticizing agents and Surfactants