Table 3.
Analysis of fold change (FC) of neutralizing antibody titer to RSV from baseline among 35 RSV-positive patients.
| Variable | FC < 4 (n=12)n (%) | FC ≥ 4 (n=22)n (%) | ORa | 95% CIa | p-valuea | Adjusted ORb | 95% CIb | p-valueb |
|---|---|---|---|---|---|---|---|---|
| Birth date | ||||||||
| < 7 months | 7 (58) | 4 (18) | Ref. | |||||
| ≥ 7 months | 5 (42) | 18 (82) | 6.3 | (1.4, 33.9) | 0.02 | |||
| Virus type | ||||||||
| RSV A | 9 (75) | 19 (86) | Ref. | Ref. | ||||
| RSV B | 3 (25) | 3 (14) | 0.5 | (0.1, 3.0) | 0.41 | 0.3 | (0.0, 1.9) | 0.19 |
| Viral load | ||||||||
| < 16 (copies/mL) | 6 (50) | 11 (52) | Ref. | Ref. | ||||
| ≥ 16(copies/mL) | 6 (50) | 10 (48) | 0.9 | (0.2, 3.8) | 0.90 | 0.6 | (0.1, 3.1) | 0.56 |
| Viral shedding | ||||||||
| <15 days | 6 (50) | 10 (46) | Ref. | Ref. | ||||
| ≥15 days | 6 (50) | 12 (54) | 1.2 | (0.3. 4.9) | 0.80 | 1.7 | (0.3, 8.7) | 0.50 |
| Symptoms | ||||||||
| URTIs | 10 (83) | 7 (32) | Ref. | Ref. | ||||
| LRTIs | 2 (17) | 15 (68) | 10.7 | (2.1, 83.2) | 0.01 | 11.1 | (1.9, 107.8) | 0.01 |
95% CI, 95% confidence interval; FC, fold change; LRTIs, lower respiratory tract infections; OR, odds ratio; RSV, respiratory syncytial virus; URTIs, upper respiratory tract infections.
In columns 4, 5, and 6, the odds ratios of the 4r-fold change between the 2 modalities of the variable of interest and the corresponding 95% CI and p-value are obtained by a simple logistic regression model.
In columns 7, 8, and 9, the adjusted OR of the 4-fold change between the 2 modalities of the variable of interest and the corresponding 95% CI and p-value are obtained by a multiple logistic regression model including birth date as an adjusting factor.