Fig. 1.

Change in whole-cell currents by a burst of 25, 500-ps pulses (190 kV/cm, 1 kHz). (A-C) Current-voltage curves for NG108, RHN, and CHO cells recorded immediately prior to psEP (open symbols) and after it (filled symbols; the voltage step protocol started 1 s after psEP and took 3 s). Mean±s.e. for 8–10 cells in each group; for clarity, error bars are shown in one direction. Note a different vertical scale in panel C (CHO cells). Sham exposures caused no appreciable change in currents (data not shown). (D) Currents due to the new conductance pathway created by psEP in the same three cell lines. Each curve was obtained by subtracting pre-psEP currents from post-psEP currents in individual cells, followed by averaging the data across the group. See text for more details.