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. 2015 Nov 9;9(5):394–403. doi: 10.1080/19336896.2015.1111507

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© 2015 The Author(s). Published with license by Taylor & Francis

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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FIGURE 5. — Comparison of PrP^Sc and prion infectivity between the crude homogenate and 20K-sup. (A) Comparison of PrP^Sc amounts between the crude homogenate and 20K-sup. The relative protein load in each lane is indicated on the top. Nl indicates the uninfected mouse brain. PrP was detected with anti-PrP mAb SAF84; 1x indicates 0.25 mg brain equivalent. Molecular markers are indicated on the left side of the blot. (B) The relationship between incubation time (mean days ± standard error) and infectious units (log LD₅₀/gram of the brain) in mice inoculated with serial dilutions of the crude homogenate (black circles and solid line; y = 16.642 – 0.061312x, where y is log LD₅₀ and x is the incubation period) and the 20K-sup (blue squares and dotted line y = 17.474 – 0.060916x).