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. 2016 Apr 12;6(3):e1176634. doi: 10.1080/2159256X.2016.1176634

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© 2016 Taylor & Francis

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Figure 3. — Suitable mechanism for Loc-103275158 predicted protein based on tandem transmembrane segments. BLAST of HLA-A11 versus M. leucophaeus, C. atys, and T. syrichta unusual MHC-I like molecules (A; regions of homology shown as blocks, red > > black). Sequence alignment of M. leucophaeus A-11L second transmembrane segment against putative dual MHC-I like molecule of C. atys and the T. syrichta, Loc-103275158 (B). Proposed mechanism for conformational change in Loc-103275158 provisional protein in the inhibition of Nef-mediated re-trafficking of MHC-I [C (domain rotations not scalar); see text]. ML (MHC-I like), NL (Nef-like), Y-motif (orange rectangle), phosphoryl (purple pentagon).