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. Author manuscript; available in PMC: 2016 Jul 28.
Published in final edited form as: Lancet. 2010 Dec 13;376(9758):2086–2095. doi: 10.1016/S0140-6736(10)61508-5

Table 3. Impact of intervention on recovery from ICD-10 CMD at 6 months among ICD-10 definite CMD cases at baseline (primary analysis), and ICD-10 depression and anxiety cases at baseline (secondary analyses), by facility type.

Diagnostic group at baseline Type of facility
p-value for effect modification
All facilities PHC GPs
Primary: ICD-10 cases (all) (n=1961)
  Collaborative Stepped Care 620 (65.0%) 369 (65.9%) 251 (64.1%)
  Enhanced Usual Care 553 (52.9%) 267 (42.5%) 286 (65.9%)
  Risk difference (95% CI) 12.1% (1.6%, 22.5%) 23.4% (5.0%, 41.7%) -1.8% (-17.7%, 14.1%) 0.001
  Risk ratio (95% CI) 1.22 (1.00, 1.47) 1.55 (1.02, 2.35) 0.95 (0.74, 1.22) 0.001
  P-value 0.05 0.04 0.63

Secondary: Depression cases (n=673)
  Collaborative Stepped Care 142 (53.6%) 80 (52.1%) 62 (55.1%)
  Enhanced Usual Care 216 (50.4%) 114 (38.8%) 102 (65.5%)
  Risk difference (95% CI) 3.2% (-9.4%, 15.7%) 13.3% (-10.1%, 36.6%) -10.4% (-29.0%, 8.1%) 0.008
  Risk ratio (95% CI) 1.05 (0.81, 1.36) 1.34 (0.73, 2.45) 0.82 (0.60, 1.12) 0.007
  P-value 0.69 0.25 0.18