Table 2. Risk of lower cognitive scores on the MOCA or MMSE with increased markers of hypertensive arteriopathy.

Odds ratios (OR) are derived from ordinal regression for the risk of being in a lower category of each score: no impairment, mild impairment or significant impairment. ORs are given per 10 μmol/L for creatinine.

	MOCA			MMSE
	OR	CI	P-val	OR	CI	P-val
Univariate Model
Creatinine	3.99	(2.06 – 7.73)	<0.001*	2.16	(1.08 – 4.33)	0.029*
Stroke vs TIA	1.53	(1.06 – 2.19)	0.022*	1.23	(0.81 – 1.85)	0.33
Leukoaraiosis
Any	2.02	(1.39 – 2.94)	<0.001*	1.60	(1.05 – 2.46)	0.03*
Moderate/Severe	2.09	(1.42 – 3.06)	<0.001*	1.34	(0.87 – 2.07)	0.18
Adjusted Model
Creatinine	2.81	(1.35 – 5.85)	<0.001*	1.81	(0.83 – 3.94)	0.14
Stroke vs TIA	1.52	(1.05 – 2.21)	0.03*	1.20	(0.79 – 1.81)	0.40
Leukoaraiosis
Any	1.25	(0.82 – 1.90)	0.30	1.06	(0.66 – 1.72)	0.81
Moderate/Severe	1.33	(0.88 – 2.02)	0.18	0.91	(0.57 – 1.46)	0.70