Table 1.
Summary of the parameters
c | Cost of glycolysis |
x | Frequency of cells with increased glycolysis in the population |
j | Number of cells with increased glycolysis in the neighbourhood |
n | Neighbourhood size |
d | Value of (j/n) above which b decreases with j (self‐poisoning) |
h 1 | Inflection point of b for j < d·n |
h 2 | Inflection point of b for j > d·n |
s 1 | Steepness of b at h 1 |
s 2 | Steepness of b at h 2 |
β | Benefit of completely acidic environment |
y | Cost of maximum level of self poisoning |
f | Cost of increased motility |
ξ | Fraction of the original acidity left after therapy |