Table 2.

Meta-analysis results for the first two examples.

Example	Model	Measure	Effect type	Estimate	95% CI	$\widehat{\tau }$	BoS % (equation (12))	$Bo{S}_r^{\prime RV}\hspace{0.17em}\%$ (equation (16))
Hypertension	Uni	SBP	MD	−10.16	(−12.06, −8.27)	2.68	–	–
(section 5.1)	Uni	DBP	MD	−4.58	(−5.59, −3.57)	1.47	–	–
	Uni	CVD	HR	0.78	(0.69, 0.89)	0.00	–	–
	Uni	Stroke	HR	0.68	(0.59, 0.79)	0.00	–	–
	Multi	SBP	MD	−10.22	(−12.14, −8.30)	2.73	0.9%	−2.4%
	Multi	DBP	MD	−4.63	(−5.67, −3.60)	1.51	0.5%	−5.1%
	Multi	CVD	HR	0.79	(0.69, 0.91)	0.05	4.2%	−8.3%
	Multi	Stroke	HR	0.73	(0.61, 0.87)	0.14	20.8%	−57.2%
Fibrinogen	Uni	Part	HR	1.41	(1.33, 1.49)	0.10	–	–
(section 5.2)	Uni	Full	HR	1.31	(1.22, 1.42)	0.07	–	–
	Multi	Part	HR	1.41	(1.33, 1.50)	0.11	1.9%	−8.4%
	Multi	Full	HR	1.31	(1.25, 1.38)	0.07	53.3%	53.1%

‘Uni’ indicates that the results are obtained from univariate meta-analyses and ‘Multi’ indicates that the results are obtained from multivariate meta-analyses. ‘MD’ denotes mean difference and ‘HR’ denotes hazard ratio. Analyses were performed on the mean difference and log hazard ratios scales; $\widehat{\tau }$ is the estimated between-study standard deviation on the mean difference and log hazard ratio scales and the BoS statistics are also on these scales. The estimated between study correlations in the multivariate meta-analysis for example one are (SBP, DBP): 0.79, (SBP, CVD): −0.31 (SBP, Stroke): −0.53 (DBP, CVD): −0.83 (DBP, Stroke): −0.94, (CVD, Stroke): 0.97. The estimated between-study correlation in the multivariate meta-analysis for example two is 1.

SBP:systolic blood pressure; SBP: systolic blood pressure; CVD: cardiovascular disease; Part: partially adjusted effect of fibrinogen level; Full: fully adjusted effect of fibrinogen level.