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. Author manuscript; available in PMC: 2016 Nov 26.
Published in final edited form as: Nature. 2016 May 4;533(7604):561–564. doi: 10.1038/nature17666

Extended Data Figure 4. G5G8 heterodimer interface.

Extended Data Figure 4

a, Sitosterolaemia mutation positions R419 (G5) and G574 (G8) at the G5-TMH2 and G8-TMH5 interface near the extracellular surface. b, Separation between the +4 glycine of G5 Walker A (G5, GSSGSGKT) and G8 Signature (LSGGE) motifs. c, Superposition of the nucleotide-free NBDs of TM287/288 (PDB accession number 4Q4H), BtuD (PDB accession number 2QI9), and Atm1 (PDB accession number 4MYC) with varying distances between NBDs. d, Left: surface-filled view of the NBDs of G5G8 showing contacts between the two half-transporters at the cytoplasmic apex. Middle: interaction between conserved NPFDF (G5) and NPADF (G8) sequences (grey dots). Right: closest distances between the two half-transporters.