. 2016 Jul 28;12(7):e1005763. doi: 10.1371/journal.ppat.1005763

Table 2. Antiprotozoal Malaria Box compounds with activity in biological assays and lacking toxicity at therapeutic levels.

Selectivity Index, SI, is toxicity level/activity level; p, probe-like; d, drug-like.

Antiprotozoal positives
Cryptosporidium parvum (SI>20)	Trypanosoma brucei (positive in all three screens, and SI >10)	T. cruzi (Scynexis screen)	T. cruzi (Maes screen)	Leishmania donovani amastigotes axenic (extracellular):	Toxoplasma gondii	Babesia spp. (3) AND Theileria equi	Babesia spp. (3) OR Theileria equi (excluding active on all 4 spp.)	Naegleria fowleri	Neospora caninum	Perkinsus marinus
MMV665917^p	MMV020505^d	MMV006558^p	MMV001230^d	MMV000356^d	MMV007363^d	MMV006706^d	MMV000620^Bc	MMV665979^d	MMV000911^d	MMV666081^d
	MMV020548^d	MMV006706^d	MMV007907^d	MMV007907^d	MMV007791^d	MMV666093^d	MMV000653^Bbi+Bbo		MMV006309^p
		MMV006764^p		MMV011438^p	MMV666095^p	MMV396693^p	MMV000911^Bc		MMV019670^d
		MMV007571^d		MMV019127^d	MMV007881^d	MMV073843^p	MMV006764^Bbo+Bbi
		MMV011256^d		MMV665979^d	MMV006704^d	MMV665875^p	MMV007374^Bc
		MMV019199^p		MMV665987^p			MMV007557^Bc+Bbi
		MMV498479^p		MMV666686^p			MMV007808^Bc
		MMV665841^p					MMV007906^Bc
		MMV665843^d					MMV008173^Bbo+Bbi
		MMV665878^d					MMV008455^Bbi
		MMV665890^d					MMV011438^Bbo+Bbi
		MMV665899^d					MMV018984^Bc+Bbo
		MMV665908^p					MMV019199^Bbo+Bbi
							MMV019202^Bc
							MMV019670^Bc
							MMV019995^Bbi
							MMV396681^Bc
							MMV665878^Bbi
							MMV665879^Bbo+Bbi
							MMV665890^Bbo+Bbi
							MMV665908^Bbi+Bbo+Te
							MMV665939^Bbo+Bbi
							MMV665946^Te
							MMV666009^Bc+Bbi
							MMV666025^Bbo
							MMV666095^Bc
							MMV666116^Te+Bbi
							MMV666689^Bbo+Bbi