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. 2016 Jul 28;11(7):e0160077. doi: 10.1371/journal.pone.0160077

Fig 1. Down-regulation of DKK3 mRNA expression in human breast cancer.

Fig 1

(A) Real-time PCR-based DKK3 mRNA expression analysis of 30 breast tumor compared to 11 healthy breast tissue samples. (B) Box plot of the samples shown in A demonstrating a down-regulation of DKK3 mRNA in breast tumor compared to healthy breast tissue samples, especially in carcinomas of the IHC-defined triple negative breast cancer subtype (TNBC). (C) In silico DKK3 mRNA expression analysis of 791 PAM50-defined breast tumor and 113 normal breast tissue samples depicted as heat map (left) and box plot (right). Red color: high, black: intermediate, green: low DKK3 mRNA expression. Horizontal lines: grouped medians. Boxes: 25-75% quartiles. Vertical lines: range, minimum and maximum. ns: not significant, * P < 0.05, ** P < 0.01, *** P < 0.001.