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. 2016 Jul 28;11(7):e0160006. doi: 10.1371/journal.pone.0160006

Fig 1. Synergistic effects of P-CTX-1, 2, 3 on veratridine responses in SH-SY5Y cells.

Fig 1

(A) Representative veratridine-induced responses in SH-SY5Y cells pre-incubated for 300 s with 0.5 nM P-CTX-1. Blue trace, response in the absence of veratridine; green trace, response elicited by 1 μM veratridine; purple trace, response elicited by 3 μM veratridine; red trace, response elicited by 5 μM veratridine. (B-D) P-CTX-1, P-CTX-2 and P-CTX-3 (30 fM–100 nM) were added 300 s prior to addition of 1 μM (green), 3 μM (purple) or 5 μM (red) veratridine. The blue data in each panel show the response to P-CTX-1, 2 and 3 in the absence of veratridine. (B) Concentration-dependent potentiation of veratridine responses by P-CTX-1 (30 fM–100 nM). (C) Concentration-dependent potentiation of veratridine responses by P-CTX-2 (30 fM–100 nM). (D) Concentration-dependent potentiation of veratridine responses by P-CTX-3 (30 fM–100 nM). Data are presented as mean ± SEM from at least n = 3 wells and are representative of three independent experiments.