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. 2016 Jul 28;11(7):e0159930. doi: 10.1371/journal.pone.0159930

Fig 4. EphA4 EC-specific ablation increases EC proliferation, migration and tube formation.

Fig 4

Panel shows WT (A, A1) and KO (B, B1) BrdU analysis of ECs stained with DAPI (blue) and BrdU (red). (C) KO ECs have significantly increased BrdU incorporation compared to WT ECs. WT (D, D1) and KO (E, E1) EC scratch. (F) KO have greater migration rate 24 hours post scratch compared to WT EC. (G, G1) WT and (H, H1) KO ECs were seeded on growth factor-reduced matrigel to form tubes. (I) Vascular index (number of tubes x tube length) is enhanced in KO ECs compared to WT. ***P<0.001; n = 16–20 wells/group; represented as mean ± SEM.