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Expression of CYP24A1 transcripts was determined in the presence of RJW100 (grey bar) or the two new compounds PME8 and PME9 (10 μM) without (siCont) or with knockdown (siLRH-1) of hLRH-1 (left panel). SiRNA-mediated knockdown of hLRH-1 in HepG2-hLRH-1 cells expressing low levels of hLRH-1 (-Dox) was carried out as described in Materials and Methods. Relative levels of hLRH-1 transcripts after siControl or sihLRH-1 are shown (right panel).
