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. 2016 Jul 28;11(7):e0159316. doi: 10.1371/journal.pone.0159316

Fig 5. Effects of other published compounds targeting hLRH-1 compared to PME8.

Fig 5

All published agonists and antagonists were tested in HepG2-hLRH-1 cells expressing high levels (+Dox) of hLRH-1. Activating compounds were added for 16 h relative to the DMSO control (black bars) at the following concentrations: RJW100 (10 μM) [7], DLPC (20 μM) [5], PME8 (10 μM) (bolded, this study) as well as the two putative antagonist/repressors, SR1848 (10 μM) [20] and Cpd3 (10 μM) [21]. Relative levels of the hLRH-1 target, CYP24A1 (left set of bars) and the housekeeping gene, TBP (right set of bars) are shown with all values normalized to GAPDH. Error bars represents SEM and P values = **** < 0.0001.