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A) Results show the mean ± SEM occupancy determined 30 min after sc dosing in mice (open circles) or 90 min after po dosing in rats (n = 4/dose). B) Individual occupancy/exposure results for mice (open circles) and composite plot showing results for rats (closed circles) treated po (as above), sc (30 min post-dose) and experimental set shift subjects (150 min post-dose).
