Table 3. Agonist efficacy of BMS-933043, EVP-6124 and TC-5619 determined by patch clamp electrophysiology at recombinant human and rat α7 nAChRs expressed in HEK293 cells.

Agent	Species	Mean ± SEM Peak Current Ymaxobs @ 10 μM	Mean ± SEM Net Charge Ymax	Mean ± SEM Net Charge EC50 (μM)
BMS-933043	Human (n = 7)	0.24 ± 0.03	0.78 ± 0.004	0.29 ± 0.01
	Rat (n = 4)	0.27 ± 0.02	0.67 ± 0.07	0.14 ± 0.03
EVP-6124	Human (n = 4)	0.32 ± 0.05	1.36 ± 0.09	0.07 ± 0.02
TC-5619	Rat (n = 3)	0.55 ± 0.06	1.26 ± 0.02	0.08 ± 0.01