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. 2016 Jul 28;11(7):e0160042. doi: 10.1371/journal.pone.0160042

Fig 3. PGNPs block Pgp overexpression in durg-sensitive H460 cells.

Fig 3

(A) Experimental scheme for 100-day treatment of cells with PTX or PGNPs with progressively increasing the concentration of PTX. (B) Pgp expression in H460, H460PTX, and H460PGNP cells. (C) Quantification of Pgp band intensities in (B), as determined by ImageJ. *P<0.05, compared with that of H460 under the same condition; ***P<0.001, compared with that of H460 under the same condition. (D) EC50 of PTX on H460PTX and H460PGNP. EC50 (inhibitor), EC50 of PTX on H460PTX and H460PGNP in the presence of a Pgp inhibitor (Reversan). Each experiment was repeated at least three times. Data are mean±s.d.