Table 1. Histopathologic and Molecular Characteristics of 24 Patients with Amplifications in FGFR/FGF signaling.

Case No.	Histology	ER status	PR status	HER2 status	Biopsy Location	Molecular Profile
1	Ductal	Positive	Positive	Negative	Liver	ATM mutation R189K, AURKA amplification, CCND1 amplification, FGF19 amplification, ZNF703 amplification
2	Ductal	Positive	Positive	Negative	Breast	PIK3CA mutation H1047R, CCND1 amplification, MCL1 amplification, EMSY amplification, FGF19 amplification, FGF3 amplification, FGF4 amplification
3	Metaplastic	Negative	Negative	Negative	Breast	PIK3CA amplification, PTEN deletion, FGFR2 amplification, MYC amplification, TP53 mutation R273C
4	Ductal	Negative	Negative	Negative	Chest wall	FGFR2 amplification, TP53 mutation R306*, CDH1 mutation Q264*
5	Ductal	Positive	Positive	Negative	Lymph node	AKT1 mutation E17K, KIT amplification, FGFR1 amplification, MYC amplification, TP53 mutation P36fs*7, NFKBIA amplification, BCL2L2 amplification, ZNF703 amplification
6	Ductal	Positive	Positive	Negative	Metastasis	PIK3CA mutation H1047R, PIK3R1 mutation G376R, CCND1 amplification, FGFR1 amplification, MYC amplification, MCL1 amplification, FBXW7 mutation D112E
7	Ductal	Negative	Negative	Negative	Liver	FGF14 amplification, GATA3 mutation A333fs*20, IRS2 amplification
8	Ductal	Negative	Negative	Negative	Breast	TSC2 mutation G1055fs*113, FGFR1 amplification, ATM mutation V1569fs*29, MCL1 amplification, TP53 mutation L111fs*40, MYC amplification, MYST3 amplification
9	Ductal	Negative	Negative	Negative	Breast	CDKN2A mutation Y44fs*1, TP53 mutation, CCND1 amplification, CCND2 amplification, FGF19 amplification, FGF3 amplification, FGF4 amplification, FGF6 amplification
10	Ductal	Negative	Negative	Negative	Breast	PTEN deletion, FGFR1 amplification, CCNE1 amplification, MCL1 amplification, MYC amplification, TP53 mutation Y234*, BCL2L2 amplification, NPM1 truncation 5′UTR, FAM123B mutation G303D
11	Ductal	Positive	Positive	Negative	Metastasis	CCND1 amplification, FGFR1 amplification, PRKDC rearrangement, PTEN protein loss
12	Ductal	Negative	Negative	Negative	Breast	FGFR1 amplificaiton, FGFR2 amplification, CCND1 amplification, MAP2K2 amplification, MYC amplification, TP53 mutation C242fs*5, PTEN protein loss
13	Ductal	Positive	Positive	Negative	Breast	CCND1 amplification, FGFR1 amplification, ARID1A mutation Q708*
14	Metaplastic	Negative	Negative	Negative	Breast	PIK3R1 mutation Y580fs*19, CCND2 amplification, CDKN2A deletion, FGF23 amplification
15	Ductal	Positive	Negative	Negative	Liver	PIK3CA mutation E454K, BRCA2 mutation K3326*, CCND1 amplification, HRAS mutation G12D, GATA3 mutation D336fs*17, FGF19 amplification, FGF3 amplification, FGF4 amplification, MYST3 amplification
16	Ductal	Positive	Positive	Negative	Breast	PTEN mutation E7fs*9, BRCA2 mutation K3326*, CCND1 amplification, EP300 mutation P925T, FGF19 amplification, FGF3 amplification, FGF4 amplification
17	Ductal	Positive	Positive	Negative	Breast	ERBB4 amplification, HGF amplification, RICTOR amplification BCL2L2 amplification, JUN amplification, FGF10 amplification
18	Ductal	Positive	Negative	Negative	Abdomen	FGFR3 amplification, PIK3CA mutation H1047L, CCND1 amplification, TP53 mutation R249M
19	Papillary	Negative	negative	Negative	Lymph node	TP53 mutation S313fs*34, CCND1 amplification, FGF19 amplification, FGF3 amplification, FGF4 amplification
20	Ductal	Positive	Negative	Negative	Liver	PIK3CA mutation E542K, CCND1 amplification, MCL1 amplification, FGF19 amplification, FGF3 amplification, FGF4 amplification, GATA3 mutation I362fs*49+, MAP2K4 mutation E299*
21	Ductal	Positive	Not Known	Negative	Breast	PIK3CA mutation E545K, PIK3CA mutation Q546H, ATM mutation R2832C, CCND1 amplification, ARID1A mutation R1528*, FGF19 amplification, FGF3 amplification, FGF4 amplification
22	Ductal	Positive	Negative	Negative	Breast	PTEN loss, KRAS amplification, MYC amplification, CCND2 amplification, TP53 mutation V272M, RB1 loss, FGF23 amplification, FGF6 amplification, KDM5A amplification
23	Ductal	Positive	Positive	Negative	Breast	PTEN splice 1087_1088ins47+, TSC2 mutation N363fs*29, FGFR1 amplification, CCND1 amplification, MDM2 amplification, MYC amplification, TP53 mutation P278T, MDM4 amplification, FGF19 amplification, FGF3 amplification, FGF4 amplification, MYST3 amplification, ZNF703 amplification
24	Ductal	Positive	Negative	Negative	Breast	CCND1 amplification, Ep300 mutation P925T, FGF19 amplification, FGF4 amplification