Skip to main content
. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Steroids. 2016 Mar 24;111:100–112. doi: 10.1016/j.steroids.2016.03.010

Table 2.

Effects of HA (histamine) and NMDA (N-Methyl-D-Aspartate) on current injection-induced depolarization

Test Agent HA NMDA
Latency to 1st
AP or Peak
(ms)		 Pre Agent 174 ± 77 102 ± 26
+
Agent		 102 ± 66 50 ± 9
Δ, % of Pre ↓ ↓
p* (n) <0.02a
(7)		 <0.05 (10)
Relative
Depol.
(mV)		 Pre Agent 11.3 ±
4.2		 20.9 ± 2.6
+
Agent		 18.5 ± 5.9 33.7 ± 4.2
Δ, % of Pre ↑ ↑
p* (n) <0.02 (7) <0.001
(10)
Depolarization
Rate (mV/s)		 Pre Agent 417 ±
189		 400 ± 125
+
Agent		 823 ±
294		 942 ± 182
Δ, % of Pre ↑ ↑
p* (n) <0.05 (7) <0.001
(10)
AP Threshold
(mV)		 Pre Agent −28.5 ±
3.9		 −31.7 ±
2.4
+
Agent		 −30.6 ±
3.5		 −29.0 ±
7.2
Δ, % of Pre ↓ ↓
pa (n) <0.02a
(7)		 <0.01 (10)
# of A P /10
sec after 1st
AP		 Pre Agent 2.43 ±
0.61		 8.9 ± 3.6
+
Agent		 3.86 ±
0.70		 13.8 ± 3.9
Δ, % of Pre ↑ ↑
p* (n) <0.02 (7) <0.02 (10)
*

Matched-pair t test, 2-tailed.

a

Wilcoxon Match-pairs Signed-ranks Test, 2-tailed.