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. Author manuscript; available in PMC: 2016 Nov 30.
Published in final edited form as: Lab Invest. 2016 May 30;96(8):895–908. doi: 10.1038/labinvest.2016.61

Figure 7. Liraglutide treatment suppresses apoptosis in HFCD-fed WT mice but not in CHOP−/− mice.

Figure 7

(A) Representative immunofluorescence images of liver tissue sections stained with terminal deoxynucleotidyl transferase (TUNEL; green) to detect apoptotic cells. (B) Representative western blot images and (C-F) densitometry measurements of hepatic cleaved caspase 3, BCL-2, Bax and LC-3B expressions in WT and CHOP−/− mice fed a ND or HFCD for 16 weeks. After 12 weeks of feeding, mice received daily injections of saline (sal) or Liraglutide (Lira) for 4 weeks. Data are presented as mean ± SEM; n = 5-7 mice per group. Hashtags indicate significant differences (p < 0.05) between ND- or HFCD-fed mice. Stars indicate significant differences (p < 0.05) between WT and CHOP−/− mice. “o” indicate significant differences (p < 0.05) between saline or Liraglutide treated mice. Scale 20 μm.