Figure 2. Increased levels of truncated tau expression and caspase activity in the forebrains of aged mice correlates with age-related loss of memory and motor function.

(a–b) Correlation analysis revealed that cleaved tau (CTau) expression in the forebrain was negatively associated with bridge walking performance ((A) Learning Index) (P=0.0008, R²=0.4713) and swim maze performance ((B) Average Latency to Fall) (P=0.468, R²=0.2020). (c) Similarly, increased caspase activity also negatively associated with bridge walking (Learning Index) (P<0.0001, R²=0.7630) and (d) swim maze performance (Average Latency to Fall) (P=0.0049, R²=0.3631). Green squares represent young mice, blue triangles represent aged mice. Linear regressions are shown as solid lines; dotted lines represent 95% confidence intervals.