Table 4.
Incidence and severity of peripheral retinal degeneration in F344/N male and female rats treated with acrylamide in drinking water for two years.
| 2-year bioassay of acrylamide |
Acrylamide (mM) | |||||
|---|---|---|---|---|---|---|
| 0 | 0.0875 | 0.175 | 0.35 | 0.70 | ||
| Males | ||||||
| Retinal degeneration, peripheral | 40/42c (95%)a | 40/47 (85%) | 38/46 (83%) |
45/46 (98%) |
41/44 (93%) |
|
| Average severityb | 1.8 | 1.8 | 1.9 | 1.8 | 1.9 | |
| Females | ||||||
| Retinal degeneration, peripheral | 43/45 (96%) | 46/46 (100%) | 45/46 (98%) |
40/44 (91%) |
41/46 (89%) |
|
| Average severity | 1.9 | 1.9 | 1.9 | 2.0 | 1.9 | |
a
: Frequency
b
: Average severity grade of lesions in affected eyes: 1 = mild, 2 = moderate, 3 = marked
c
: Fifty animals per group were initially assigned to each study however some animals were excluded from the assessment because of improper specimen handling, post mortem autolysis or due to early deaths.