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. Author manuscript; available in PMC: 2017 Jul 27.
Published in final edited form as: Cell Syst. 2016 Jun 23;3(1):83–94. doi: 10.1016/j.cels.2016.05.008

Figure 5. Relation of recombination to piRNA loci.

Figure 5

(A) Recombination enrichment at repeat-derived piRNA-matched loci with respect to the whole-genome average. Repeat-derived loci with 100% identity to some sequence deposited in piRNA-Bank (Sai Lakshmi and Agrawal, 2008) were classified as belonging to SINE, LINE, SVA or other family of repetitive elements. Recombination enrichments were computed using the British (GBR) recombination map.

(B) Enrichment for recombination, CpG sites and sperm methylation for loci matched by four specific repeat-derived piRNA (piRNA-Bank accession numbers DQ577359, DQ579099, DQ577145 and DQ571358). The location of transposable elements and their 5’-and 3’-ends are shown in black. Predicted PRDM9 binding motifs conserved across different loci are indicated in red. The origin of coordinates corresponds to the location of the piRNA-matched sequence. In the four cases the piRNA sequence is antisense to the transposable element.

(C) Enrichment for recombination (top left), predicted PRDM9 binding sites (top right) according to the motif CCNCCNTNNCCNC, sperm CpG methylation (bottom left), and sperm H3K4me3 and H3K27me3 marks (bottom right) for the loci considered in (A).

See also Figure S4.