Table 2.
Example 1 is described in Section 3.1; (*) indicates that model estimation initiates after the 20th patient has been treated at level 6. Examples 2 and 3 illustrate rigidity (Section 3.2); the trial is confined to d2 and d5 respectively, no matter how many consecutive non-DLT's occur at that level.
| Example 1 | Example 2 | Example 3 | ||||||
|---|---|---|---|---|---|---|---|---|
| Dose | No of DLTs | No of patients treated | Patient | No of DLTs | Dose | Dose | No of DLTs | No of patients treated |
| 1 | 1 | 4 | 1 | 0 | 1 | 1 | 0 | 1 |
| 2 | 1 | 3 | 2 | 0 | 2 | 3 | 0 | 1 |
| 3 | 1 | 4 | 3 | 1 | 3 | 5 | 1 | 3 |
| 4 | 1 | 4 | 4 | 0 | 1 | 6 | 1 | 1 |
| 5 | 1 | 3 | 5 | 0 | 2 | |||
| 6 | 0 | 2* | 6 | 1 | 2 | |||
| 3 | 0 | 1 | ||||||