Table 2.
hVMAT2 (119,000,584-119,038,941in chr10) promoter marker association with PD (risk=APL and AAO=Monk’s) in US Caucasian nuclear families
| SNP# (alleles) BP | Stratification* | Nuclfams | Allele_freq | P-values from association tests | |
|---|---|---|---|---|---|
| APL | Monks | ||||
| rs363371 | Overall | 734 | 0.229076 | 0.3214 | 0.8654 |
| (A/G) | eo40 | 75 | 0.232207 | 0.11614 | 0.2982 |
| 118986396 | lo40 | 659 | 0.228686 | 0.601914 | 0.3267 |
| [-14.188]ζ | eo60 | 447 | 0.224322 | 0.326581 | 0.46 |
| lo60 | 287 | 0.236826 | 0.624936 | 0.4812 | |
| rs363324 | Overall | 730 | 0.294713 | 0.739958 | 0.0523 |
| (A/G) | eo40 | 75 | 0.29139 | 0.045055 | 0.1446 |
| 118989162 | lo40 | 655 | 0.295247 | 0.698848 | 0.6880 |
| [-11.422] | eo60 | 447 | 0.289271 | 0.31641 | 0.0283 |
| lo60 | 283 | 0.303743 | 0.524848 | 0.2628 | |
| rs10689256 | Overall | 731 | 0.303918 | 0.455899 | 0.0282 |
| (-/TG) | eo40 | 76 | 0.311232 | 0.016872 | 0.0788 |
| 118996351-2 | lo40 | 655 | 0.302962 | 0.911098 | 0.6319 |
| [-4.233] | eo60 | 448 | 0.301251 | 0.203136 | 0.0141 |
| lo60 | 283 | 0.308828 | 0.827434 | 0.2913 | |
| rs2619096 | Overall | 731 | 0.321018 | 0.501831 | 0.0476 |
| (C/T) | eo40 | 75 | 0.333655 | 0.013646 | 0.1287 |
| 118998127 | lo40 | 656 | 0.31938 | 0.833793 | 0.6598 |
| [-2.457] | eo60 | 447 | 0.316884 | 0.237695 | 0.0322 |
| lo60 | 284 | 0.328856 | 0.897904 | 0.1762 | |
| rs34074668 | Overall | 732 | 0.31724 | 0.828607 | 0.061 |
| (-/TAA) | eo40 | 75 | 0.318634 | 0.031013 | 0.1088 |
| 118998525-7 | lo40 | 657 | 0.317143 | 0.602034 | 0.6086 |
| [-2.059] | eo60 | 449 | 0.313661 | 0.357332 | 0.0479 |
| lo60 | 283 | 0.324404 | 0.579364 | 0.3383 | |
# rs#/alleles/BP by GRCh37.p13;
*Age stratification: cut-off 40 years: eo40 (AAO<40), lo40 (AAO≥40); cut-off 60 years: eo60 (AAO<60), lo60 (AAO≥60)
ζ Position in promoter (transcription start site = +0.001kb)