Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic of excision of integrated HIV-1 proviral DNA by (CRISPR)/CRISPR-associated 9 (Cas9). A guide RNA (gRNA) specific for the HIV-1 long terminal repeat (LTR) present at each end of the HIV-1 proviral genome is used together with Cas9. This results in cleavage at 2 sites that flank the HIV-1 genome and consequently the excision and subsequent degradation of the proviral DNA
