Fig. 2.

Comparison of MEMRI enhancement between controls and MPTP-intoxicated mice at day 7. (A) MEMRI enhancement maps. The first column (from left) shows coronal slices of the averaged MEMRI of control mice (n = 5) as an anatomical reference. The sagittal slice (upper left) shows respective coronal positions (red lines). The second column shows the average enhancement in control mice on the coronal slices. The third column represents the average enhancement of MPTP-intoxicated mice (n = 6). The fourth column represents the average enhancement of MPTP-intoxicated mice treated with 15 μg LBT-3627. The fourth column represents the average enhancement of MPTP-intoxicated mice treated with 45 μg LBT-3627. The color bar for the enhancement maps is at the top of the figure. Dark blue color (0 %) means no change in enhancement from Mn²⁺ compared with preinjection signal intensity. Dark red color represents 90 % signal increase compared to preinjection signal intensity. (B) Statistical comparison of MEMRI enhancement between MPTP-intoxicated mice and MPTP-intoxicated mice treated with 15 μg LBT-3627. It shows the pixels (red color) with significant decrease (p < 0.05) in signal intensity overlaid onto the averaged brain image