Fig. 2.

Neuropathological changes in rabies viral encephalitis. (A) Pyramidal neurons of cerebral cortex show multiple characteristic eosinophilic intracytoplasmic Negri bodies (arrows). Note the well-preserved neuronal morphology of infected neurons without evidence of neuronal degeneration and prominent nucleoli. (Inset) Rabies viral nucleocapsid antigen seen as fine, stippled deposits and occasional larger aggregates within the cytoplasm within the magnocellular neurons of the brain stem reticular formation (hematoxylin and eosin × 240; inset: immunoperoxidase for rabies viral antigen × 320). (B) Microglial nodules surrounding a degenerating neuron (arrow). Note absence of Negri bodies within the degenerating neuron (hematoxylin and eosin × 280). (C) Perivascular lymphocytic cuffing around the parenchymal vessels in the brain stem in a case of rabies encephalitis (hematoxylin and eosin × 120)