Table 1. Clinical characteristics and laboratory findings of IVIG responders and non-responders.
| Responders (n=585) | Non-responders (n=118) | p* | |
|---|---|---|---|
| Clinical characteristics | |||
| Male sex (%) | 339 (57.9) | 62 (52.5) | 0.946 |
| Age (month) | 31.62±22.71 | 33.31±21.97 | 0.457 |
| Fever duration before IVIG (day) | 5.87±1.87 | 5.65±2.16 | 0.265 |
| Fever duration after IVIG (day) | 0.52±0.89 | 3.23±2.28 | <0.001 |
| Total fever duration (day) | 6.38±1.96 | 8.86±3.06 | <0.001 |
| Laboratory findings (continuous variables) | |||
| Sodium (mmol/L) | 137.18±2.62 | 136.16±2.55 | <0.001 |
| Total bilirubin (mg/dL) | 0.56±0.63 | 1.02±1.03 | <0.001 |
| AST (IU/L) | 70.36±129.25 | 118.89±214.53 | 0.019 |
| ALT (IU/L) | 73.03±124.87 | 125.51±175.94 | 0.002 |
| Albumin (g/dL) | 4.13±1.22 | 3.91±0.48 | 0.056 |
| CRP (mg/dL) | 6.47±6.05 | 7.45±5.93 | 0.106 |
| Hct (%) | 33.03±2.73 | 32.79±3.26 | 0.402 |
| WBC (×103/µL) | 13.19±5.24 | 13.75±6.34 | 0.370 |
| Platelet (×103/µL) | 351.32±120.23 | 333.45±160.52 | 0.253 |
| Neutrophil (%) | 56.78±18.47 | 64.23±17.83 | <0.001 |
| Laboratory findings (categorical variables) | |||
| Sodium<134 (mmol/L) | 46 (7.9) | 16 (13.6) | 0.047 |
| Total bilirubin ≥0.9 (mg/dL) | 65 (11.1) | 40 (33.9) | <0.001 |
| AST≥80 (IU/L) | 94 (16.1) | 44 (37.3) | <0.001 |
| ALT≥45 (IU/L) | 191 (32.6) | 62 (52.5) | <0.001 |
| Albumin<3.5 (g/dL) | 38 (6.5) | 21 (17.8) | <0.001 |
| CRP≥8 (mg/dL) | 175 (29.9) | 46 (39.0) | 0.053 |
| Hct<31 (%) | 120 (20.5) | 31 (26.3) | 0.165 |
| WBC>12 (×103/µL) | 323 (55.2) | 65 (55.1) | 0.980 |
| Platelet<300 (×103/µL) | 203 (34.7) | 54 (45.8) | 0.023 |
| Neutrophil≥80 (%) | 49 (8.4) | 25 (21.2) | <0.001 |
Data are presented as either mean±standard deviation or percentage. *Analyzed by an unpaired t-test or a Chi-square test. IVIG: intravenous immunoglobulin, AST: aspartate aminotransferase, ALT: alanine aminotransferase, CRP: C-reactive protein, Hct: hematocrit, WBC: white blood cell