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. 2016 Jul 29;7:284. doi: 10.3389/fimmu.2016.00284

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Copyright © 2016 Cheng, Plumb, Lai, Abraham and Dutz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Epicutaneous CpG ODN enhances P- and E-selectin ligand expression in CD4 antigen-specific T cells. C57BL/6 mice adoptively transferred with CD4⁺ Thy1.1⁺ OT-II T cells were immunized with scOVA ± ecCpG ODN. Skin draining lymph nodes were collected for flow cytometric analysis 3 days post-immunization. (A) Representative flow cytometric plots of CD4 Thy1.1 double-positive cells showing selectin ligand expression. (B) The percentage of single-positive cells for CD62L, PSL, or ESL among CD4⁺ Thy1.1⁺ cells in the skin draining lymph nodes. Bar graphs show the mean ± SD of 4 individual experiments, n = 9. Statistical significance of all three groups was analyzed by one-way ANOVA test with a Tukey’s multiple comparison post hoc analysis. *p < 0.05.